Research is an integral part of our culture at Peninsula Health as it underpins the aim of the provision of high-quality evidence-based intensive care medicine.
The ICU Research team is led by Prof Ravi Tiruvoipati and Mr David Zhang. With extensive expertise in trial design and implementation, the team drives innovative studies to evaluate and improve ICU practices.
We lead and collaborate on investigator-led and industry-supported multicentre trials, supervising and mentoring junior professionals across allied health, medicine, and nursing in completing research higher degrees, and supporting junior doctors to fulfill the formal research project requirements of the College of Intensive Care Medicine (CICM).
Current research studies
BEST-DKA: This randomised clinical trial will determine whether fluid therapy with Plasma-Lyte® 148 reduces the number of days in hospital compared to treatment with 0.9% sodiumchloride in ED patients presenting with moderate-severe diabetic ketoacidosis
BONE ZONE: This randomised clinical trial will determine the effect of subcutaneous denosumab or intravenous zoledronic acid vs placebo on preventing bone loss in females aged >50 years and males aged >70 years in the year following ICU admission
ECCO2R in reducing the lung injury in mechanically ventilated patients: This study aims to assess the utility of an ECCO2R device called Prismalung in reducing ventilator induced lung injury in intubated patients who have a driving pressure (ΔP) > 14 and/or Plateau pressure >/= 25, elevated respiratory rate with hypercarbia and acidaemia
ECHONOF III: This randomised clinical trial will assess whether focused cardiac ultrasound before hip surgery leads to better clinical outcomes forpatients with isolated, primary fractured neck of femur who are planned for surgery within 2 days of their admission
REACT Shock: This randomised clinical trial will compare individually-tailored mean arterial pressure targets versus the standard approach of blood pressure management in patients aged >40 years who present in a shock state
SODa-BIC: This randomised clinical trial will determine whether an infusion of sodium bicarbonate diluted in 5% dextrose, compared with an infusion of 5% dextrose alone, reduces 30-day Major Adverse Kidney Events for patientswith metabolic acidosis and vasopressor dependency
SPICE IV trial: This randomised control trial will determine whether the use of Dexmedetomidine as a primary sedative agent in intubated patients aged >65 years reduces 90-day all-cause mortality
Our Collaborators
We have close link to the University of Melbourne, Monash University and ANZICS Clinical Trials Group as well as national and international collaborators.