ICU Research

Research is an integral part of the Department’s culture as it underpins the aim to provide high quality evidence-based intensive care. The last decade has seen substantial progress in critical care-related research generated from the Department of Intensive Care.

The establishment of a national database has provided an invaluable tool for research activities. This database has been in existence in various forms since 1990 when the decision was made by Australian and New Zealand Intensive Care Society (ANZICS) to collect national information about ICU resource allocation, patient demographics and patient outcome. The national database known as AORTIC (Australian Outcomes Research Tool for Intensive Care) stores raw data and undertakes calculations to provide the Acute Physiology, Age, & Chronic Health Evaluation (APACHE III) and Simplified Acute Physiology (SAPS) score for each patient. Metropolitan and Regional Intensive Care Units generate routine reports from their own in house databases and submit these electronically on a regular basis to the national database run by ANZICS.

Research interests at Frankston Intensive Care Unit are varied and include sedation, renal replacement therapy, nutrition, echocardiography and ultrasound, extracorporeal techniques mechanical ventilation and sepsis. The department has been a member of the ANZICS Clinical Trials Group (CTG) for many years and has collaborated on numerous multi-center trials. Links with industry have provided grants for further trials.

Collaboration with Fisher Paykel has created opportunities for evaluating methods of oxygen delivery and this data has led to international presentations and publications in peer reviewed journals.

Associate Professor Ravi Tiruvoipati is the Director of ICU Research and is PhD candidate with Monash University and is investigating the role of C02 in mechanically ventilated patients. He has extensive experience in ECMO and was one of the lead investigators of the landmark CESAR study published in the Lancet. Prof Botha is a past member of The Sedation and Analgesia Advisory Board in Intensive Care (SAABIC) and multi centre research in ICU delirium and Sedation was completed with this group. He has been site investigator of numerous CTG trials and was on the Management Committee of the NHMRC funded Nephroprotect Trial. Dr Kavi Haji is a PhD candidate with Melbourne University and her thesis is on the role of bedside echocardiography and ultrasound on management of the critically ill.  The Research Co-ordinator is Mr Cameron Green who has an MSc from the University of Edinburgh for his work on Delirium.

Please use the links below to view a list of our current and past research activities, research collaborations, and a list of our publications, invited presentations, and research awards

 

Current Research Projects

Below is a list of the Research Projects currently being undertaken in Frankston Hospital ICU.

 

ATHOS-3

A randomised controlled trial investigating the use of Angiotensin-II for patients with catecholamine resistant shock

TARGET Trial

A multi-centre randomised controlled double-blind trial investigating the impact of energy-dense enteral nutrition on the outcomes of critically ill patients, when compared to standard enteral nutrition.

Nebulised Heparin Trial

A multi-centre randomised controlled trial of nebulised heparin for the prevention of lung injury in mechanically ventilated patients. 

H.I.T. Trial

An investigation of the role of induced Hyperthermia in the treatment of critically ill patients with sepsis.

HAEMOLUNG Trial

Investigation of the use of Haemolung Respiratory Assist System (RAS) for management of severe hypercapnia among mechanically-ventilated critically ill patients

ULTRAWEAN

Evaluation of respiratory and cardiac Ultrasound in predicting outcomes of weaning from mechanical ventilation. The aim of the study is to evaluate the use of Ultrasound in predicting outcomes of weaning from MV by analyzing diaphragmatic movement, systolic and diastolic Left Ventricle function, and detecting worsening or newly developing pulmonary oedema.

 


Past Research Projects

Below is a list of completed Research Projects that Frankston Hospital has participated in.

 

DELAYED DISCHARGE STUDY

This study compares differences in outcomes between patients who have their discharge from ICU delayed with those who have no delay in discharge

TRANSFUSE Trial

A multi-centre randomised controlled trial investigating the impact of transfusing the freshest-available Red Blood Cells (RBC), when compared to standard practice (transfusing the oldest-available RBC), on patient outcomes.

PAV+ Trial

A randomised controlled trial comparing two modes of spontaneous supported ventilation, Pressure Support Ventilation (PSV) to Proportional Assist Ventilation (PAV+), on patient outcomes, including length of mechanical ventilation and ICU length of stay.

Impact of Delay in Rapid Response Call activation on Patient Outcomes

This study aimed to investigate the impact of delay in activation of a rapid response call on patient outcomes including unplanned ICU admission and in-hospital mortality

ROMPIS Validation

This study aimed to develop and validate the first ever scale for the assessment and monitoring of pressure injuries to the mouth and lips.

Sleep in the ICU – Pilot Study

An investigation of the self-reported quality of sleep among non-mechanically ventilated patients admitted to the Intensive Care Unit.

ARISE

This multi-center will evaluate the effect of Goal Directed Therapy on septic patients admitted to the Emergency Department.

ITRAC

Impact of routine transthoracic echocardiography and respiratory ultrasound assessment in critical care. The study aims to evaluate the role of routine focused transthoracic echocardiography and respiratory ultrasound in the assessment of critically ill patients as extended clinical examination.

UARDM

Ultrasound assessment of regional diaphragmatic movement and the correlation with subphrenic organ displacement in critically ill patients. The aims of the study are to evaluate the correlation of movement between parts of the hemidiaphragm, assess the correlation between liver or spleen displacement and movement of the ipsilateral hemidiaphragm, and identify the most reliably imaged regions of the diaphragm.

Refeeding Syndrome Trial

A multi-centre randomised controlled trial investigating the use of caloric management for the treatment of Refeeding Syndrome among critically ill patients

NEPHROPROTECT TRIAL

This NHMRC prospective study investigated whether an amino acid infusion protected the kidney from acute kidney injury during an ICU admission

Post RENAL study

This study evaluated the renal status of patients who survived an episode of acute renal failure in the ICU

CHEST (Crystalloid versus Hydroxyethyl Starch Trial)

A multi-centre randomised controlled trial of fluid resuscitation with starch (6% hydroxyethyl starch 130/0.4) compared to saline (0.9% sodium chloride) in intensive care patients on mortality.

EARLY PARENTERAL NUTRITION STUDY

This study determined the benefits of starting parenteral nutrition earlier than would normally be started under standard care, and whether early TPN improved survival measured at 60 days after commencement of treatment.

SPICE

This multi-centre study investigated sedation practice and the incidence of ICU delirium

STATINS in Sepsis

A multi-center study evaluating the effect of statin drugs on inflammatory mediators and patient outcomes in patients with sepsis

INFINITE 2009

A prospective study, observing the patient population admitted to Intensive Care with H1N1 and Influenza A.

TAME (Time and Money Evaluation) Study

An audit of the time and financial cost involved in the review process of multi-centre clinical trials in Australia and New Zealand

The DARE (Discharge and Readmission Evaluation) Study

Multi-centre study evaluating the impact of ICU discharge and re-admission on patient outcomes

PROTECT

This trial evaluated the effect of Low Molecular Weight Heparin (LMWH) vs. Unfractionated Heparin (UFH) on proximal leg Deep Vein Thrombosis, Pulmonary Embolism and confirmed bleeding

RENAL

Multi-centre randomised controlled trial assessing the effect of augmented vs. normal Continuous Renal Replacement Therapy (CRRT) on survival of Intensive Care Unit Patients with Acute Renal Failure (ARF)

SEMI-RECUMBENT POSITIONING IN VENTILATED PATIENTS

A multi-centre observational study to evaluate the use of semi-recumbent positioning and the degree of backrest elevation in patients receiving mechanical ventilation in Australia and New Zealand ICU’s.

ENTERIC STUDY

An investigation of whether early jejunal feeding (using a frictional nasojejunal tube) increased the amount of enteral nutrition delivered during ICU admission in mechanically ventilated critically ill patients with reduced gastric motility, when compared to standard feeding (using a naso-gastric tube).

AKI-EPI (Acute kidney Injury – Epidemiologic Prospective Investigation)

An evaluation of the epidemiology and early management of AKI according to the RIFLE classification in ICU patients.

ASAP (Audit of Severe Acute Pancreatitis Feeding Practices)

CRITICAL CARE NUTRITION (Improving the Practice of Nutrition Therapy in the critically ill: International Nutrition Survey)

BLOOD USE IN ICU

A prospective observational study of blood product transfusion practices in Australian Intensive Care Units

EPIC II

The extended study of prevalence of infection in Intensive Care Unit

A COMPARISON OF HIGH FLOW NASAL OXYGEN TO HIGH FLOW FACE MASK OXYGEN

A randomized crossover study comparing high-flow face mask oxygen to high-flow nasal prong oxygen delivery in recently actuated patients

RICH (Rapid Infusion of Cold Hartman’s Solution)

A pilot study and randomised controlled trial evaluating the efficacy of Cold Hartman’s solution in out of hospital cardiac arrest outcome

DEVELOPING AND EVALUATING EVIDENCE BASED GUIDELINES FOR FEEDING IN THE INTENSIVE CARE UNIT – A CLUSTER RANDOMISED TRIAL

This trial was a multi-centre cluster randomized trial evaluating the impact of applying evidence based nutritional guidelines on mortality in the intensive care unit.

BEST (Beginning and Ending Supportive Therapy for the Kidney Study)

 


Publications

Our ICU consultants and Researchers have published extensively in peer-reviewed medical Journals. 

 2016 | 2015 |2014 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 |

2017

Gupta, S., Green, C., Subramaniam, A., Zhen, LD., Low, E., Tiruvoipati, R. (2017). The impact of delayed rapid response call activation on patient outcomes. Journal of Critical Care, 6 (41)

Tiruvoipati, R., Pilcher, D., Buscher, H., Botha, J., Bailey, M. (2017). Effects of hypercapnia and hypercapnic acidosis on hospital mortality in mechanically ventilated patients. Critical Care Medicine (epub ahead of print, DOI: 10.1097/CCM.0000000000002332)

Subramaniam, A., Pick, A., Tiruvoipati, R. (2017). Anterior spinal artery syndrome after double valve replacement and coronary artery bypass surgery. Clinical Case Reports (epub ahead of print; doi.: 10.1002/ccr3.928)

Green, C., Hendry, K., Wilson, E., Walsh, T., Allerhand, M., MacLullich, AJM., Tieges, Z. (2017). A novel computerised test for detecting and monitoring visual attentional deficits and delirium in the intensive care unit. Critical Care Medicine (epub ahead of print, DOI:10.1097/CCM.0000000000002477)

Haji, K. & Royse, A. (2017) Sonographic evaluation of the diaphragm morphology and function in the critically ill. Annals of Translational Medicine, 5 (1) 

Molloy, J., Pratt, N., Green, C., Tiruvoipati, R., Plummer, V. Relationship between diurnal patterns in Rapid Response Call activation and patient outcome. Australian Critical Care (epub ahead of print, DOI: 10.1016/j.aucc.2017.01.009).

Bloomer, MJ., Clarke, AB., Morphet, J. (2017). Nurses’ prioritisation of enteral nutrition in intensive care units: a national survey. Nursing in Critical Care (epub ahead of print, DOI: 10.1111/nicc.12284)

 

2016

Subramaniam, A., Grauer, R., Beilby, D., Tiruvoipati, R. (2016) Anesthetic management of a myotonic dystrophy patient with paraganglionoma. Journal of Clinical Anaesthesia, 34

Khalil, V., deClifford, JM., Lam, S., Subramaniam, A. (2016) Implementation and evaluation of a collaborative clinical pharmacist’s medications reconciliation and charting service for admitted medical inpatients in a metropolitan hospital. Journal of Clinical Pharmacy and Therapeutics, 41 (6)  

Foster, E., Bonavia, L., Green, C., Subramaniam, A., Tiruvoipati, R. (2016). A descriptive study of patients with Guillain-Barre syndrome: experience from an Australian tertiary level hospital. Australian Medical Journal, 9 (8)

Tiruvoipati, R., Buscher, H., Winearls, J., Breeding, J., Ghosh, D., Chaterjee, S., Braun, G., Paul, E., Fraser, JF., Botha, J. (2016). Early experience of a novel extracorporeal carbon dioxide removal device in management of acute hypercapnic respiratory failure. Critical Care and Resuscitation, 18 (4)

Morphet, J., Clarke, A., Bloomer, M. (2016). Intensive care nurses’ knowledge of enteral nutrition: a descriptive questionnaire. Intensive & Critical Care Nursing (epub ahead of print, DOI: 10.1016/j.iccn.2016.07.001)

Reaper, S., Green, C., Gupta, S., Tiruvoipati, R. (2016). Inter-rater reliability of the Reaper Oral Mucosa Pressure Injury Scale (ROMPIS): a novel scale for the assessment of the severity of pressure injuries to the mouth and oral mucosa. Australian Critical Care, 30 (3)

Banakh, I., Lam, A., Tiruvoipati, R., Carney, I., Botha, J. (2016). Imatinib for bleomycin induced pulmonary toxicity: a case report and evidence-base review. Clinical Case Reports, 4 (5); 486 – 490

Haji, K., Royse, A., Green, C., Botha, J., Canty, D., Royse, C. (2016) Interpreting diaphragmatic movement with bedside imaging. Journal of Critical Care, 34; 56-65 

Reade, MC., Eastwood, GM., Bellomo, R., Bailey, M., Bersten, A., Cheung, B., Davies, A., et al. (2016). Effect of Dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomised clinical trial. JAMA 315 (14)

Sathianathan, K., Tiruvoipati, R., Vij, S. (2016). Prognostic factors associated with hospital survival in comatose survivors of cardiac arrest. World Journal of Critical Care Medicine, 5 (1), 103 – 110

Subramaniam, A., Botha, J., Tiruvoipati, R. (2016). The limitations in implementing and operating a rapid response system. Internal Medicine Journal, 46 (10) 

Stewart, J., Tiruvoipati, R. (2016). Factors influencing quality of sleep among non-mechanically ventilated patients in the Intensive Care Unit. Australian Critical Care, 30 (2)

Ridgeon, E., Bellomo, R., Myburgh, J., …, Green, C., et al. (2016). Validation of a classification system for causes of death in critical care: an assessment of inter-rater reliability. Critical Care and Resuscitation, 18 (1)

 

2015

Doig, GS., Simpson, F., Heighes, PT., Bellomo, R., et al. for the Refeeding Syndrome Trial Investigators Group (2015). Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respiratory Medicine, 3 (12), 943 – 952 

Haji, K., Butler, E., Royse, C. (2015). A case of chronic inflammatory demylenating polyneuropathy with reversible alternating diaphragmatic paralysis: a case study. Critical Ultrasound Journal, 7 (16).

Green, CR., Botha, JA., Tiruvoipati, R. (2015). Cognitive function, quality of life, and mental health among survivors of out-of-hospital cardiac arrest: a review. Anaesthesia and Intensive Care 43 (5), 568 – 576.

Gupta S., Tiruvoipati R., Green C., Botha J., Tran, H. (2015) Heparin induced thrombocytopenia in critically ill: Diagnostic dilemmas and management conundrums. World Journal of Critical Care Medicine 4(3): 202-12.

Gupta, S., Tiruvoipati, R., Green, C. (2015). Atrial fibrillation and mortality in critically ill patients: a retrospective study. American Journal of Critical Care, 24 (4), 336 – 341

Doig, GS., Simpson, F., Bellomo, R., Heighes, PT., Sweetman, EA., Chesher, D., Pollock, C., Davies, A., Botha, J., Harrigan, P., & Reade, MC. (2015). Intravenous amino acid therapy for kidney function in critically ill patients: a randomised controlled trial. Intensive Care Medicine, 41 (7), 1197 – 1208 

Botha, J., O’Brien, Y., Malouf, S., Cole, E., Ansari, ES., Green, C., Tiruvoipati, R. (2015). The outcome and predictors of mortality in patients therapeutically cooled postcardiac arrest. Journal of Intensive Care Medicine 31 (9)

Haji, K., Royse, A., Tharmaraj, D., Haji, D., Botha, J., Royse, C. (2015). Diaphragmatic regional displacement assessed by ultrasound and correlated to subphrenic organ movement in the critically ill patients – an observational study. Journal of Critical Care, 30 (2). 439.e7-13

Gujadhur, A., Tiruvoipati, R., Cole, E., Malouf, S., Ansari, ES., Wong, K. (2015). Serum bicarbonate may independently predict acute kidney injury in critically ill patients: an observational study. World Journal of Critical Care Medicine, 4 (1), 71 – 75.

Gattas, DJ., Rajbhandari, D., Buhr, H., Bellomo, R. (2015). A randomised controlled trial of regional citrate versus regional heparin anticoagulation for continuous renal replacement therapy in critically ill adults. Critical Care Medicine, 18: 472

 

2014

The ARISE Investigators and ANZICS Clinical Trials Group (2014). Goal-directed resuscitation for patients with early septic shock. New England Journal of Medicine, 371, 1496 – 1506.

Subramaniam, A., Tiruvoipati, R., Botha, J. (2014). Is cooling still cool? Therapeutic Hypothermia and Temperature Management, 5 (1)

Ali A., Botha J., Tiruvoipati R. (2014) Fatal skin and soft tissue infection of multidrug resistant Acinetobacter  baumannii: A case report. Int J Surg Case Rep. 5(8), 532-536

Majumdar, M., Vuat, J., Lambert, K. (2014). Attitudes to end-of-life issues and organ and tissue donation amongst medical staff: A single-centre survey. Transplant Journal of Australasia, 23 (2)

Tiruvoipati, R., Gupta, S., Haji, K., Braun, G., Carney, I., Botha, JA. (2014). Management of severe hypercapnia post cardiac arrest with extracorporeal carbon dioxide removal. Anaesthesia and Intensive Care, 42 (2)

POST-RENAL Study Investigators (2014). Long-term survival and dialysis dependency following acute kidney injury in intensive care: extended follow-up of a randomised controlled trial. PLOS Medicine, 11 (2)

Tiruvoipati, R., Haji, K., Gupta, S., Braun, G., Carney, I., Botha, J. (2014). Low veno-venous extracorporeal Carbon Dioxide removal in management of severe status asthmaticus – a case report. The Clinical Respiratory Journal

 

2013

Botha, J., Tiruvoipati, R., & Goldberg, D. (2013). Futility of medical treatment in current medical practice. NZJM, 126 (1383)

Shekar, K., Davies, AR., Mullany, DV., Tiruvoipati, R., Fraser, JF. (2013). To ventilate, oscillate, or cannulate? J Crit Care, 28 (5), 655-662

Tiruvoipati, R., Botha, J. (2013) Carbon dioxide Clearance in Critical Care. Anesthesia and Intensive Care, 41 (1)

RENAL study Investigators and ANZICS Clinical Trials Group (2013) Early acid-base and blood pressure effects of continuous renal replacement therapy intensity in patients with metabolic acidosis. Intensive Care Med, 39 (3): 429-36

 

2012

The Australian ICU Liaison Nurse Forum (2012) Uptake and caseload of intensive care unit liaison nurse services in Australia. Critical Care and Resuscitation, 14 (3): 221-225

Haji, K., Tiruvoipati, R., Botha, J., Haji, D. (2012) Two case reports of colchicine overdose: An uncommon and potentially difficult diagnosis. Crit Care & Shock, 15: 120-123

CHEST Investigators (2012) Hydroxyethyl starch or saline for fluid resuscitation in intensive care. NEJM, 367: 1901-1911

Tiruvoipati, R., Sultana, N., Lewis, D. (2012) Cardiac troponin I does not independently predict mortality in critically ill patients with severe sepsis. Emerg Med Australas, 24(2):151-8.

Tiruvoipati, R., Chiezey, B., Lewis, D., Ong, K., Villanueva, E., Haji, K., Botha, J. (2012) Stress hyperglycemia may not be harmful in critically ill patients with sepsis. J Crit Care., 27(2):153-8.

Rapid Infusion of Cold Hartmann’s (RICH) Investigators (2012). Induction of prehospital therapeutic hypothermia after resuscitation from nonventricular fibrillation cardiac arrest. Crit Care Med, 40 (3): 747-753

Subramaniam, A., McPhee, M., & Nagappan, R. (2012). Predicting energy expenditure in sepsis: Harris-Benedict and Schofield equations versus the Weir derivation. Critical Care and Resuscitation, 14 (3), 202 – 210

Chua, HR., Baldwin, I., Bailey, M., Subramaniam, A., Bellomo, R. (2012). Circuit lifespan during continuous renal replacement therapy for combined liver and kidney failure. Journal of Critical Care 27 (6).

Tiruvoipati, R., Botha, J., Peek, GJ. (2011) Effectiveness of extracorporeal membrane oxygenation when conventional ventilation fails: valuable option or vague remedy? J Crit Care, 27 (2): 192-198

 

2011

Ho, KM., Hart, G., Austin, D., Hunter, M., Botha, J., Chavan, S. (2011) Dose-related effect of smoking on mortality in critically-ill patients: a multicenter cohort study. Intensive Care Med, 37: 981-989

Lewis, D., Chiezey, B., Tiruvoipati, R. (2011). Elderly patients are more prone for hypoglycaemia while in intensive care. Australian Critical Care, 24 (1): 62

Lewis, D., Tiruvoipati, R., Walker, L. (2011). The frequency of blood glucose monitoring in septic patients in the intensive care unit: a retrospective audit. Australian Critical Care, 24 (1): 71

The Blood Observational study Investigators (2011). Age of red blood cells and mortality in the critically ill. Critical Care, 15 (R116)

The PROTECT investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials (2011). Dalteparin versus unfractionated Heparin in critically ill patients. NEJM, 364: 1305-1314

 

2010

Tiruvoipati, R. & Botha, J. (2010) Prone ventilation for severe hypoxic respiratory failure: Lacking evidence but probably not efficacy. British Journal of Intensive care, Autumn 2010

Rapid Infusion of Cold Hartmann’s (RICH) Investigators (2010). Induction of therapeutic hypothermia from out-of-hospital ventricular fibrillation cardiac arrest: a randomised controlled trial. Circulation, 122: 737-742

Shehabi, Y., Botha, JA., Ernest, D., Freebairn, RC., Reade, M., Roberts, BL., Seppelt, I., Weisbrodt, L. (2010). Clinical application, the use of dexmedetomidine in intensive care sedation. Crit Care & Shock, 13: 40-50

Peek, GJ., Elbourne, D., Mugford, M., Tiruvoipati, R., Wilson, A., Allen, E., Clemens, F., Firmin, R., Hardy, P., Hibbert, C., Jones, N., Killer, H., Thalanany, M., & Truesdale, A. (2010) Randomised controlled trial and parallel economic evaluation of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR). Health Technol Assess., 14(35):1-46

Haji, K., Haji, D., Tiruvoipati, D., Bailey, M., Le Blanc, V., Botha, J. (2010) Impact of length of stay in emergency department on the outcome in patients with severe sepsis. Crit Care and Shock, 13: 132-137

Tiruvoipati, R., Ong, K., Gangopadhyay, H., Arora, S., Carney, I., Botha, J. Hypothermia predicts Mortality in elderly patients with Sepsis. BMC Geriatr, 10(1):70

The ANZIC Influenza Investigators and Australasian Maternity Outcomes Surveillance System (2010). Critical illness due to 2009 A/H1N1 influenza in pregnant and postpartum women: population based cohort study. BMJ, 340

Bloomer, M., Tiruvoipati, R., Tsiripillis, M., Botha J. (2010) End of life management of adult patients in an Australian metropolitan Intensive Care Unit: A retrospective observational study. Australian Critical Care, 23: 13-19

Tiruvoipati, R., Lewis, D., Ong, K., Gupta, M., Haji, K., Botha, J. (2010). Impact of glycemic control on survival in critical care patients with sepsis. Crit Care, 14 (Suppl. 1): P572

Haji, K., Tiruvoipati, R., Bailey, M., Le Blanc, V., Botha, JA. (2010). Impact of length of stay in emergency department on the outcome in patients with severe sepsis. Crit Care & Shock, 13: 132-137

The BEST Kidney Investigators (2010). Cost of acute renal replacement therapy in the intensive care unit: results from the Beginning and Ending Supporting Therapy for the Kidney (BEST Kidney) study. Critical Care, 14 (R46)

Subramaniam, A., Cooke, JC., Ernest, D. (2010). “Inverted” tako-tsubo cardiomyopathy due to exogenous catecholamines. Critical Care and Resuscitation, 12 (2), 104 – 108.

Subramaniam, A., Corallo, C., & Nagappan, R. (2010). Daspone-associated methaemoglobinaemia in patients with a haematologic malignancy. Anaesthesia and Intensive Care, 38 (6)

 

2009

The RENAL Replacement Therapy Study Investigators (2009). Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients. NEJM, 361 (17)

The ANZIC Influenza Investigators (2009). Critical Care Services and 2009 H1N1 Influenza in Australia and New Zealand. NEJM , 361

The Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators (2009) Extracorporeal membrane oxygenation for 2009 Influenza A(H1N1) acute respiratory distress syndrome. JAMA, 302 (17)

Tiruvoipati, R., Lewis, D., Haji, K. & Botha, J. (2009) High-flow nasal oxygen vs high-flow face mask: A randomised crossover trial in extubated patients. Journal of Critical care, 25 (3): 463-468

The RENAL Replacement Therapy Trial Investigators (2009) Screening and Study Enrolment in the Randomised and Evaluation of Normal vs. Augmented level (RENAL) Replacement Therapy Trial. Blood Purif , 27: 199-205

The ANZIC Influenza Investigators (2009) Critical care services and 2009 H1N1 influenza in Australia and New Zealand. NEJM, 361 (20): 1925-1934

Duke, GJ., Buist, MD., Pilcher, D., Scheinkestel, CD., Santamaria, JD., Gutteridge, GA., Cranswick, PJ., Ernest, D., French, C., Botha, JA. (2009) Interventions to circumvent intensive care access block: a retrospective two-year study across metropolitan Melbourne. MJA, 190:375-378

Peek, GJ., Mugford, M., Tiruvoipati, R., Wilson, A., Allen, E., Thalanay, MM., Hibbert, CL., Truesdale, A., Clemens, F., Cooper, N., Firmin, RK., Elbourne, D. (2009). Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicenter randomised controlled trial. Lancet, 374: 1351-1363

Adamidies, AA., Rosenfeldt, FL., Winter, CD., Pratt, NM., Tippett, NJ., Lewis, PM., Bailey, MJ., Cooper, DJ., Rosenfeld, JV. (2009). Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury. J Am Coll Surg, 209 (4): 531-539

Majumdar, M., Simes, DC., & Prabha, RD. (2009). Cerebritis: an unusual complication of Klebsiella pneumonia. Indian J Crit care Med, 13 (1): 37-40

 

2008

RENAL Study Investigators (2008) Design and Challenges of the Randomised Evaluation of Normal versus Augmented Level Replacement Therapy (RENAL) Trial: High-Dose versus Standard Dose Hemofiltration in Acute Renal Failure. Blood Purif, 26: 407-416

RENAL Study Investigators (2008) Renal replacement therapy for acute kidney injury in Australian and New Zealand intensive Care Units: a practice survey. Critical Care and Resuscitation, 10 (3): 225-230

Nutrition Guidelines Investigators of the ANZICS Clinical Trials Group (2008) Effect of evidence –based feeding guidelines on mortality of critically ill patients: A cluster randomised controlled trial. JAMA, 300 (23)

Shehabi, Y., Botha, J., Boyle, M., Ernest, D., Freebairn, R., Jenkins, I., Roberts, B., Seppelt, I. (2008) Sedation and Delirium in the ICU: An Australian Perspective. Anaesthesia and Intensive Care, 36 (4)

Botha, JA., Tiruvoipati, R., Last, GC., Somjen, G., Chue, WL. (2008) Predictors of outcome of ruptured aortic aneurysms in a metropolitan hospital. Anaesth Intensive Care. 36(4):560-4.

Chalwin, RP., Tiruvoipati, R., Peek, GJ. (2008) Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygenation. Eur J Cardiothorac Surg. 34(3): 685-6.

Thalanany, MM., Mugford, M., Hibbert, C., Cooper, NJ., Truesdale, A., Robinson, S., Tiruvoipati, R., Elbourne, DR., Peek, GJ., Clemens, F., Hardy, P., Wilson, A.; CESAR Trial Group (2008) Methods of data collection and analysis for the economic evaluation alongside a national, multi-centre trial in the UK: conventional ventilation or ECMO for Severe Adult Respiratory Failure (CESAR). BMC Health Serv Res. 30 (8):94.

Tiruvoipati, R., Bangash, M., Manktelow, B., Peek, GJ. (2008). Efficacy of prone ventilation in adult patients with acute respiratory failure: a meta-analysis. J Crit Care, 23(1): 101-10.

Haji, K., Le Blanc, V., Haji, D., Botha, J. (2008) The effect of prolonged Emergency Department length of stay on inpatient length of stay and in-hospital mortality in severe sepsis and septic shock. Critical Care, 12(Suppl 2): P418

Tiruvoipati R., Ong, K., Walker, L., Arora, S., Carney, I., Botha, J. (2008). Sepsis in Elderly Patients –Are there early predictors of mortality? Anaesth Intensive Care, 35 (6): 1011-1012

Tiruvoipati R., Ong, K., Walker, L., Gangopadhyay, H, Botha, J., Carney, I. (2008) Predictors of Intensive Care Unit Mortality in Patients with Sepsis. Anaesth Intensive Care, 35 (6): 1011-1011

 

2007

Tiruvoipati, R., Moorthy T., Balasubramanian, SK., Platt, V., Peek, GJ. (2007). Extracorporeal membrane oxygenation and extracorporeal albumin dialysis in paediatric patients with sepsis and multi-organ dysfunction syndrome. The International Journal of Artificial Organs, 30 (3): 227-234

Tiruvoipati, R., Vinogradova, Y., Faulkner G., Sosnowski, AW., Firmin, RK., Peek, GJ. (2007). Predictors of outcome in patients with congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation. Journal of Paediatric Surgery, 42: 1345-1350

Tiruvoipati, R., Pandya, H., Manktelow, B., Smith, J., Dodkins, I., Elbourne, D., Field, D. (2007) Referral pattern of neonates with severe respiratory failure for extracorporeal membrane oxygenation. Arch Dis Child Fetal Neonatal Ed, 93

 

2006

Nagappan, R., Botha, J., Copland, J., Carney, I., Vij, J. (2006) Oxford Mini Vaporiser for Halothane in Ventilated Asthmatics. Critical Care, 10(Suppl 1): P62

 

2005

The BEST Kidney Investigators (2005) Acute Renal Failure in Critically Ill Patients: a multinational, multicenter study. JAMA, 294 (7): 813-818

B.E.S.T. Kidney Investigators (2005) External validation of severity scoring systems for acute renal failure using a multinational database. Critical Care Medicine, 33(9):1961-1967

Botha, J., Mudholkar, P., Le Blanc, V. (2005) The Effect of Changing from Pressure Support to Volume Control Ventilation on Renal Function . Crit Care and Resusc., 7(4): 303-9

Botha, J., & Le Blanc V. (2005) The State of Sedation in the Nation, results of a national survey. Crit Care and Resusc., 7(2): 92-96.

Naka, T., Moritoki, E., Bellomo, R., Cole, L., French, C., Botha, J., Wan, L., Fealy, N., Baldwin, I. (2005) Commercial low citrate anticoagulation haemofiltration in the high risk patient with frequent filter clotting. Anaesthesia and Intensive Care, 33(5): 601-608.

 

 

 


Presentations

Botha, J., Green, C., Carney, I., Haji, K., Gupta, S., Tiruvoipati, R. Proportional Assist Ventilation versus Pressure Support Ventilation as weaning modes for mechanically ventilated patients, World Congress of Anaesthetists, Hong Kong (2016)

Stewart, J., Green, C., Stewart, J., Tiruvoipati, R. Factors influencing quality of sleep among non-mechanically ventilated patients in the Intensive Care Unit, 2nd Annual Regional Critical Care Conference, Bendigo (2016)

Toakley, C., Green, C. ISBAR-ICU: development and implementation of a standardised ICU clinical handover tool – nursing perceptions, barriers and challenges, 12th Congress of the WFCCN, Brisbane (2016)

Reaper, S., Green, C., Gupta, S., Tiruvoipati, R. Development and Validation of a Scale for the Assessment of Pressure Injuries to the Mouth and Oral Mucosa: Reaper Oral Mucosa Pressure Injury Scale (ROMPIS), ANZICS/ACCCN ASM, Melbourne (2014)

Pratt, N., Molley, J., Tiruvoipati, R., White, S., Simms, K. The When, where, why and impact of Rapid Response Calls in a Metropolitan Hospital, 7th Annual International Conference on Rapid Response and Medical Emergency Teams, Sydney (May 2012)

Molloy, J.H.M., Pratt, N.M., Reaper, S., Botha, J., Tobias, T. The First 12 months of the critical care liaison service. ANZICS, Melbourne (2010)

Pratt, N.M., Molloy, J.H.M., Botha, J., Tobias, T., White, S., Simms, K.  A ten year check up for a rapid response system – revitalizing our medical emergency team. ANZICS, Melbourne (2010)

Tiruvoipati, R., Chiezey, B., Lewis, D., Ong, K., Villanueva, E., Haji, K., Botha, J. Evidence of reduced mortality with stress hyperglycaemia in critically ill patients with sepsis. ANZICS, Melbourne (2010)

Lewis, D., Chiezey, B., Tiruvoipati, R. Elderly patients are more prone for hypoglycaemia while in intensive care. ANZICS, Melbourne (2010)

Reaper, S., Allen-Terry, C., Clinkaberry, A., Conroy, S., Kohlman, D., Leatch, L. & Macey, A. H1N1 Influenza A: The Complexities and Care Required for a Bariatric Patient in Intensive Care. 8th Annual ACCCN Victorian Symposium on Critical Care (2010)

Haji, K., Le Blanc V., Haji, D., Botha J. The effect of prolonged Emergency Department length of stay on inpatient length of stay and in-hospital mortality in severe sepsis and septic shock. International Intensive Care and Emergency Symposium, Brussels (March 2007)

Shehabi, Y., Botha, J., Boyle, M., Ernest, D., Freebairn, R., Jenkins, I., Roberts, B., Seppelt, I. Sedation and Delirium in the ICU: An Australian Perspective. ANZICS, Rotorua (Oct. 2007)

Botha, J., Tiruvoipati, R., Tsiripillis, M., Bloomer, M., Walker, L., Hanna, D. End of Life Decisions in the ICU: A single centre study. ANZICS, Rotorua (Oct. 2007)

Lewis, D., Tiruvoipati, R., Botha, J. A Comparison of High Flow Nasal Oxygen with Face Mask Oxygen in Extubated Patients. ANZICS, Rotorua (Oct. 2007)

Botha, J., Cameron, D., Broughton, S., Carney, I., Trevaskis, K., Taylor, P. Implementation of an infection control plan decreases blood stream infection (BSI) rate and MRSA acquisition in an ICU. ANZICS, Rotorua (Oct. 2007).

Tiruvoipati, R., Ong, K., Walker, L., Gangopadhyay, H., Carney, I., Botha, J. Predictors of Intensive Care Unit Mortality in patients with Sepsis. ANZICS, Rotorua (Oct. 2007)

Tiruvoipati, R., Ong, K., Walker, L., Arora, S., Botha, J., Carney, I. Sepsis in Elderly Patients – are there early predictors of Mortality? ANZICS, Rotorua (Oct. 2007)

Arora, S., Botha, J., Tiruvoipati, R. Wolff Parkinson White Syndrome can present as sudden cardiac arrest. ANZICS, Rotorua (Oct. 2007)

Nagappan, R., Botha, J., Copland, J., Carney, I., Vij J. Oxford Mini Vaporiser for Halothane in Ventilated Asthmatics. ANZICS, Adelaide (Oct. 2005)

Nagappan, R., Botha, J., Carney, I., Butler, E., Day, T. Myoclonus does not always predict poor prognosis in Anoxic Brain Injury. ANZICS, Cairns (Sept. 2003)

Botha, J., Priestley, I., Carney, I., Nagappan, R., Marshall, S., Heckmann, K. The Outcome of Ruptured Aortic Abdominal Aneurysms admitted to a Metropolitan Hospital.  ANZICS, Cairns (Sept. 2003)

Botha, J. & Mitra, D. Vasopressin; A therapeutic option in Massive Pulmonary Embolism. RACP meeting, Hobart (May 2003)

Nagappan, R., Botha, J., Carney, I. Hypoxic Brain Injury. ANZICS CTG Meeting, Noosa (2003)

Shehabi, Y. & Botha, J. Dexmedetomidine for Sedation.

Botha, J. & Le Blanc, V. The State of Sedation in the Nation: results of an Australian Survey. ANZICS, Perth (2002)

Botha, J., Mudholkar, P., Le Blanc, V., Braun, G. Ventilation of patients with Obstructive Pulmonary Disease: Intensive Care Outcome. ANZICS, Perth 2002

Botha, J., Mathieson , Carney, I., Le Blanc, V. An Audit of Glucose Control in a Multidisciplinary Intensive Care Unit. ANZICS, Perth 2002

Mulder, J. & Botha, J. The definition of Acute Renal Failure: Results of an International Survey. ANZICS, Perth (2002)

Botha, J., Mudholkar, P., Vasic, N., Udin, R. Renal function during changes from volume control to pressure support ventilation.  Eighth World Congress of Intensive Care, Sydney, Australia (2001)

Botha, J., Mudholkar, P., Langton, D., Pugh, J., Kohlman, D., Gardner, B., Robinson, E. The effect of a sedation scale on ventilation hours and sedative use. Victoria Eighth World Congress of Intensive Care, Sydney (2001) 

 

Collaborations

Frankston Hospital ICU collaborates on research projects with a number of Industry and Professional Bodies.

 

ANZICS CTG – RENAL, Early PN, Enteric, STATINS, ARISE, CHEST, DARE, TRANSFUSE

Canadian CTG – PROTECT

The George Institute – RENAL

SAABIC – Sedation in Intensive Care

Fisher Paykel –Oxygen Therapy

European Society for Intensive Care Medicine (ESICM) – EPIC II

European Critical Care Research Network – AKI EPI

Parexel International/Eli Lilly – PROWESS SHOCK

The Austin Hospital – A randomised controlled study of two different anticoagulation regimens on filter life during Continuous Venovenous Haemofiltration (CVVH)

 


Research Grants

 

Doig GS, Bellomo R, Davies AR, Simpson F, Reade M, Pollock C, Chesher D, Harrigan P, Devarajan, P, Botha J and Sweetman EA. Nephro-protective effects of L-amino acids in critically ill patients: A multi-centre randomized controlled trial. National Health & Medical Research Council Project Grant $829,300

Tiruvoipati, R., Haji, D., Haji, K., Villanueva, E., Chiezey, B., Allsop, S., Rosengarten, P., Botha, J. Role of hyperthermia in the treatment of critically ill patients with sepsis- A randomised controlled trial. Peninsula Health Small grants for health research 2011, $3,150

Tiruvoipati R., Botha, J., Fletcher, J., Gangopadhyay, H., Majumdar, M., Villanueva, E., Vij, S. Evaluation of clinical outcomes and cost consequences of delayed discharge from intensive care: A multicentre prospective observational study. 2011 ANZICS SAFETY, QUALITY AUDIT & OUTCOMES GRANT. $15,000

Abbots J., Lewis D., Tiruvoipati R. Hydrocolloid dressing versus foam dressing for the treatment of pressure ulcers in intensive care patients – A pilot randomized control trial. Peninsula Health Small grants for health research 2012, $3000.

Vuat J. Raising awareness of organ and tissue donation amongst the Aboriginal community of the Mornington Peninsula. $9964.00.

Vuat J. Regional nurses supporting community activity for raising organ donation awareness. $5,635.00

 

Research Awards

2015

Cameron Green, Sachin Gupta, Ashwin Subramaniam, Lim Dee Zhen, Elizabeth Low, Ravindranath Tiruvoipati – Best Scientific Poster (Medical Category), Peninsula Health Research Week

Kai Zheong Lim – First Prize, Student Research Prize, Peninsula Health Research Week

Elizabeth Low and Lim Dee Zhen – Second Prize, Student Research Prize, Peninsula Health Research Week

 

2014

Sue Reaper, Cameron Green, Dr. Sachin Gupta, Dr. Ravi Tiruoivpati – Best Scientific Poster (Interprofessional Category), Peninsula Health Research Week

Jodi Vuat and Jo Sanders – Best Scientific Poster (Nursing Category), Peninsula Health Research Week

John Stewart – Second Prize, Nursing Research, Peninsula Health Research Week

 

2013

Sue Reaper & Emily Vegt – ACCN Best Innovative Practice Free Paper (ACCCN Vic)

Dr Kavi Haji & Prof.  John Botha – Best Scientific Poster (Medicine Category), Peninsula Health Research Week

Joanne Molloy & Naomi Pratt – Nursing Research Prize, Peninsula Health Research Week

 

2012

John Abbots – Scientific Poster Winner (Nursing Category), Peninsula Health Research Week

Dr Ravi Tiruvoipati – Scientific Poster Winner (Medicine Category), Peninsula Health Research Week

John Abbots – Nursing Research Prize, Peninsula Health Research Week

Elizabeth Cole & Saada Malouf – Student Research Prize, Peninsula Health Research Week

 

2011

Joanne Molloy & Naomi Pratt – Nursing Research Prize, Peninsula Health Research Week

Dr Mainak Majumdar, Jodi Vuat & Kylie Lambert – Best Presentation, Donate Life National Forum

 

2010

Ashwin Subramaniam – Highly Recommended Poster, World Congress Internal Medicine

 

2009

David Lewis – Nursing Research Prize, Peninsula Health Research Week

 

2008

Dr Ravi Tiruvoipati – Best Scientific Poster (Medicine Category), Peninsula Health Research Week 

 

2007

David Lewis – Nursing Research Prize, Peninsula Health Research Week